Articles Tagged With:
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Indiana Medicaid Officials Embrace Care Coordination Project
A project to improve care coordination for children with complex medical needs revealed well-trained nurse care coordinators could manage a 100-patient caseload and improve outcomes. Nurse care coordinators were embedded in primary care provider offices and were trained to provide care coordination, including helping patients with medical and social needs.
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Pulmonary Embolism
Emergency clinicians need to remain updated on the management and treatment of many critical diagnoses. Pulmonary emboli carry a significant morbidity and mortality, even with the advances in treatment that have been made over the past several decades. Having a high suspicion, making the diagnosis early, and initiating treatment are important for optimal patient outcomes.
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Efficacy and Safety of Leriglitazone in Patients with Friedreich Ataxia
Friedreich ataxia (FRDA) is an autosomal, recessive, multisystemic disease characterized by progressive weakness, ataxia, and dysarthria starting in childhood and resulting in severe morbidity and premature death. There are no approved treatments for FRDA. With recent preclinical studies suggesting potential benefit of PPARPγ agonists in motor function and reduced radiographic disease activity, the current study explores the effect of leriglitazone, a PPARPγ agonist, in patients with moderate to severe FRDA.
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Late-Onset Pompe Disease: A Review of Clinical Features
In this systematic literature review of studies that evaluate motor and locomotion function in patients with adult, late-onset Pompe disease, the clinical spectrum reveals weakness of respiratory, axial, and proximal limb muscles.
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Can a Blood-Based Test Serve as a Biomarker for Parkinson’s Disease?
This proof-of-concept study proposes that a noninvasive assay detecting pathology-associated α-synuclein extracted from blood may reveal a reliable biomarker for Parkinson’s disease.
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Do Spinal Cord Stimulators Really Help for Chronic Pain?
A comprehensive analysis of a large clinical database regarding treatment of patients with chronic low back pain did not support the benefit of spinal cord stimulators compared to conventional medical management for chronic pain.
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Magnetic Brain Stimulation for Alzheimer’s Disease
Transcranial magnetic stimulation, targeted at the precuneus in an effort to maintain a normal default mode network, shows some promise in slowing cognitive decline and maintaining normal electrophysiology in patients with mild to moderate Alzheimer’s disease.
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Does the Completeness of Coronary Revascularization Affect the Outcome of Transcatheter Aortic Valve Replacement?
In this study of data from the REVASC TAVI registry, completeness of myocardial revascularization did not significantly affect the risk of all-cause mortality or the combined endpoint of death, stroke, myocardial infarction, or heart failure hospitalization at two years.
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Outcomes for Patients Undergoing Transcatheter Edge-to-Edge Repair for Functional Mitral Regurgitation
Researchers analyzed transcutaneous mitral valve repair in patients with moderate-to-severe or worse mitral valve regurgitation caused by cardiomyopathy and heart failure despite maximally tolerated guideline-directed medical therapy. Compared to medical therapy alone, undergoing repair resulted in fewer heart failure and other cardiovascular disease hospitalizations and significantly more time free of hospitalization and death.
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Ablation vs. Drug Therapy for Atrial Fibrillation, Revisited
A three-year follow-up of EARLY-AF, a study of relatively young and healthy patients with recent atrial fibrillation, showed cryoablation remains superior to drug therapy for preventing the development of persistent atrial fibrillation.